Molecular Characterization of AmpC β-lactamases in Enterobacteriaceae

AmpC β-lactamases are enzymes that resistant to β-lactams, such as penicillin and cephalosporin, but not cefoxitin cefotetan. This study was conducted characterize in Enterobacteriaceae. included 200 cephalosporin-resistant Gram-negative isolates recovered from different samples between January 2015 December 2016. The were subjected phenotypic tests, those tested positive further analyzed by PCR for six genotypes: ACC, DHA, FOX, CIT, MOX, EBC. Among the strains, 32% (64) methods. target genotypes detected 20 (10%) of isolates. Pus predominant source Klebsiella pneumoniae (55%) most common producer β-lactamase. CIT-FOX gene type. As there is variation prevalence geographic regions, periodic surveillance measures control infection can prevent spread these genes.